Epigenetic BRCA2 Gene in Epithelial Ovarian Cancer
نویسندگان
چکیده
منابع مشابه
epigenetic brca2 gene in epithelial ovarian cancer
background ovarian cancer is the most common fatal gynecologic malignancy in women. the brca2 gene has a role in regulation of cell cycle during proliferation, differentiation and dna repair. changes in the methylation of brca2 may be an effective mechanism for ovarian cancer. objectives the aim of the present study was to evaluate the association between ovarian cancer and methylation status o...
متن کاملpromoter methylation status and protein expression of brca2 in patients with epithelial ovarian cancer
background : ovarian cancer is the leading cause of death among gynecological cancers. changes in the methylation of brca1 and brca2 may be an effective mechanism for breast and ovarian cancer. this study evaluates the protein expression and methylation status of brca2 in iranian patients. methods : we assessed 60 mullerian-type ovarian cancers by methylation-specific pcr assays and immunohisto...
متن کاملBRCA2 N372H Polymorphism and Risk of Epithelial Ovarian Cancer
The BRCA2 N372H is the only common polymorphism that leads to the amino acid change based on the reports up to date. Previous studies explored the relationship between the single nucleotide polymorphism and ovarian cancer risk, but the results were inconsistent or inconclusive.To investigate the association between N372H in BRCA2 gene and ovarian cancer susceptibility, a systematic literature s...
متن کاملEpigenetic factors controlling the BRCA1 and BRCA2 genes in sporadic ovarian cancer.
Hypermethylation of the BRCA1 promoter has previously been shown to cause reduced mRNA expression in both breast and ovarian cancers. Nothing is yet known of the expression pattern or methylation status of the promoter region of BRCA2 in sporadic ovarian cancer. Whereas our analysis of 30 sporadic ovarian carcinomas showed a statistically significant reduction of BRCA1 mRNA expression (P = 0.00...
متن کاملserum her2 level in epithelial ovarian cancer
introduction : the proto-oncogene her2 plays a key role in the control of cellular proliferation. its overexpression has been reported to be associated with a poor prognosis in cancer, particularly in breast cancer. materials and methods : in the present study, serum her2 levels were investigated in patients diagnosed with epithelial ovarian cancer. serum her2 levels were detected by an elisa c...
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ژورنال
عنوان ژورنال: Gene, Cell and Tissue
سال: 2015
ISSN: 2345-6833,2345-6841
DOI: 10.17795/gct-28416